The former Desperate Housewives star will voice the lead character in Mother Up!, a show about a record executive who leaves her high powered job to become a stay-at-home mum.
She tells The Hollywood Reporter, ""She's a crazy, irresponsible mother, that all mothers fear they are. She barely keeps her kids alive with bizarre, improvised solutions to the endless challenges of parenting.
""I always find you have so much more freedom as an actor with your voice when you're hiding behind an animated character, as opposed to live action.""
The series, which will be co-executive produced by Longoria, will air later this year (13).
Longoria previously played unhappy housewife Gabrielle Solis in longrunning TV hit Desperate Housewives.